01 - Preheat oven to 400°F and line a baking sheet with parchment paper.
02 - In a mixing bowl, combine ground beef, cream cheese, Italian seasoning, garlic powder, onion powder, salt, and pepper. Mix until well combined.
03 - Divide the beef mixture into 8 equal portions. Flatten each portion on a sheet of parchment paper into a rectangle (about 5x3 inches).
04 - Place a few pepperoni slices and some shredded mozzarella in the center of each rectangle.
05 - Carefully roll up each rectangle around the filling, sealing the edges to prevent cheese from leaking out.
06 - Arrange the roll ups seam side down on the prepared baking sheet. Top each roll up with a sprinkle of parmesan cheese.
07 - Bake for 15 minutes, or until the beef is cooked through and the cheese is melted and bubbly.
08 - Serve hot with marinara sauce on the side for dipping, if desired.