01 - In a large bowl, whisk together buttermilk, salt, black pepper, garlic powder, and paprika. Add chicken breasts and turn to coat evenly. Cover and refrigerate for at least 30 minutes, up to 4 hours for enhanced tenderness.
02 - Combine flour, panko breadcrumbs, paprika, cayenne pepper, oregano, salt, and black pepper in a shallow dish. Stir until evenly blended.
03 - Remove chicken breasts from marinade allowing excess to drip off. Dredge each piece thoroughly in the flour mixture, pressing gently to adhere the coating.
04 - Heat vegetable oil in a large nonstick or cast-iron skillet over medium-high heat until shimmering.
05 - Place coated chicken breasts in the skillet and cook 5 to 6 minutes per side until golden brown and internal temperature reaches 165°F (74°C). Adjust heat as needed to avoid burning.
06 - Transfer chicken to paper towel-lined plate to drain excess oil. Let rest for 5 minutes before serving.